What are the median survival rates for brain metastasis?

Updated: Aug 01, 2018
  • Author: Victor Tse, MD, PhD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Generalizing median survival data for resection, WBRT, and/or stereotactic radiosurgery from available study reports is difficult.

Median survival after any therapy must be judged by means of recursive partitioning analysis (RPA) of the patients' data and by evaluating the tumor type included in the study groups. Table 2 provides an overview of data from several RTOG studies.

Table 2. Overview of RPA Data from RTOG Studies [23] (Open Table in a new window)


Karnofsky Performance Status

Systemic Disease

Median Survival, mo

Age 65 y or younger

70 or higher

Controlled primary disease; no extracranial metastases

7.1 overall; 13.5 for single metastasis, 6 for multiple metastases

Age 65 y or older

70 or higher

Uncontrolled systemic disease; extracranial metastasis

4.2 overall; 8.1 for single metastasis, 4.1 for multiple metastases

Any age




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