What is the prognosis of primary central nervous system lymphoma (PCNSL) in patients with HIV infection?

Updated: Jan 19, 2018
  • Author: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Answer

Answer

Patients with AIDS have only a 4-month median survival duration with radiation therapy. Untreated, such patients often die within 2.5 months, sometimes because of coexisting infections.

Extended survival in subgroups of HIV-infected patients with CD4+ counts greater than 200 cells/µL and no concurrent opportunistic infections have been reported. With a regimen of intrathecal methotrexate, concurrent systemic procarbazine, cyclohexylchloroethylnitrosourea (CCNU), vincristine, and whole-brain radiotherapy, this small subset of patients with AIDS had median survival durations ranging from 10-18 months.


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