What is the role of antiepileptic drugs in the treatment of primary central nervous system lymphoma (PCNSL)?

Updated: Jan 19, 2018
  • Author: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
  • Print
Answer

Answer

Prophylactic use of antiepileptic drugs (AEDs) should be avoided and their use should be confined to patients who experience seizures. Any of the first-line AEDs (eg, phenytoin, carbamazepine, valproic acid) would be appropriate for patients with PCNSL, although leukopenia and liver function abnormalities from any of these drugs potentially could be confused with chemotherapy-related toxic effects. New-generation antiepileptic drugs, such as levetiracetam (Keppra), have high efficacy and fewer side effects.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!