Which diagnostic tests are performed following a CT/MRI scan suggesting primary central nervous system lymphoma (PCNSL) in an immunocompetent patient?

Updated: Jan 19, 2018
  • Author: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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The following should be ordered in an immunocompetent patient whose computed tomography (CT)/MRI scan suggests PCNSL:

  • Withhold corticosteroids, as their use may complicate diagnosis

  • Chest radiograph to rule out metastatic disease

  • Complete blood count (CBC)

  • HIV testing

  • Slit-lamp examination for vitreous lymphoma

  • Lumbar puncture for cells, glucose, protein, and cytology in the cerebrospinal fluid (CSF)

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