Which medications in the drug class Antiparkinson Agents, Dopamine Agonists are used in the treatment of Multiple System Atrophy?

Updated: Oct 17, 2018
  • Author: André Diedrich, MD, PhD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Antiparkinson Agents, Dopamine Agonists

These agents are used as alternatives to levodopa therapy in the late phase of the movement disorder. They selectively act on different subtypes of dopamine receptors throughout the brain. The mechanism through which dopaminergic agonists act is independent of the functional capacities of the striatonigral neurons and may be more effective than those of other drugs.

Bromocriptine (Parlodel, Cycloset)

Bromocriptine is a strong agonist of D2 and a partial agonist of D1 striatal dopamine receptors.

Amantadine

Amantadine may alter dopamine release or reuptake and actions at glutamate receptors.


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