Which medications in the drug class Urinary Antispasmodic Agents are used in the treatment of Multiple System Atrophy?

Updated: Oct 17, 2018
  • Author: André Diedrich, MD, PhD; Chief Editor: Selim R Benbadis, MD  more...
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Urinary Antispasmodic Agents

When detrusor hyperreflexia is the cause of a patient's urinary incontinence, peripherally acting anticholinergic agents (eg, oxybutynin chloride [Ditropan], tolterodine [Detrol], propantheline [Pro-Banthine]) can be applied.

Oxybutynin chloride (Ditropan XL, Gelnique, Oxytrol)

Oxybutynin chloride, a tertiary amine muscarinic receptor antagonist, is a nonspecific relaxant on smooth muscles.

Tolterodine (Detrol, Detrol LA)

Tolterodine is a competitive muscarinic receptor antagonist for overactive bladder. It differs from other anticholinergics by being selective for the urinary bladder over the salivary glands. Tolterodine has high specificity for muscarinic receptors and has minimal activity or affinity for other neurotransmitter receptors and other potential targets (eg, calcium channels).


Propantheline blocks the action of acetylcholine at postganglionic parasympathetic receptor sites.

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