Which medications in the drug class Prokinetic Agents are used in the treatment of Multiple System Atrophy?

Updated: Oct 17, 2018
  • Author: André Diedrich, MD, PhD; Chief Editor: Selim R Benbadis, MD  more...
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Prokinetic Agents

If a special bulk-forming diet fails, lactulose occasionally is helpful. In rare cases, cisapride (Propulsid) may promote bowel movements, but this agent has been removed from the US market because of risk of cardiac rhythm disturbances.

Erythromycin (E.E.S., Ery-Tab, Erythrocin)

Erythromycin is a macrolide antibiotic that duplicates the action of motilin. By binding to and activating motilin receptors, it is responsible for migrating motor complex activity. IV administration enhances the emptying rate of liquids and solids. The effect can also be seen with oral erythromycin. The enteric-coated form may be the most tolerable. However, erythromycin's benefit as a prokinetic agent is usually marginal in MSA.

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