Which medications in the drug class Antihistamines are used in the treatment of Multiple System Atrophy?

Updated: Oct 17, 2018
  • Author: André Diedrich, MD, PhD; Chief Editor: Selim R Benbadis, MD  more...
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These agents prevent histamine response in sensory nerve endings and blood vessels. They are more effective in preventing histamine response than in reversing it.

Diphenhydramine (Benadryl, Diphenhist)

Diphenhydramine is a first-generation antihistamine with anticholinergic effects that binds to H1 receptors in the CNS and body. It competitively blocks histamine from binding to H1 receptors.

Diphenhydramine affects structures in the neostriatum. It has significant antimuscarinic activity and penetrates the CNS, giving the drug a pronounced tendency to induce sedation. Approximately half of patients treated with conventional doses have some somnolence.

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