What is the role of scintigraphy in the workup of multiple system atrophy (MSA)?

Updated: Oct 17, 2018
  • Author: André Diedrich, MD, PhD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Scintigraphy with iodine-123 metaiodobenzylguanidine (123 I MIBG) appears to be a useful tool for differentiation between Parkinson disease and MSA early after onset of autonomic dysfunction (90% sensitivity, 95% specificity).

Patients with Parkinson disease have significantly lower cardiac123 I MIBG uptake than do some patients with MSA and controls. However, studies have shown imperfect reliability. [31, 32]


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