How is multiple system atrophy (MSA) differentiated from corticobasal ganglionic degeneration?

Updated: Oct 17, 2018
  • Author: André Diedrich, MD, PhD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

MSA and corticobasal ganglionic degeneration

Corticobasal ganglionic degeneration is pathologically characterized by enlarged, achromatic neurons in cortical areas and nigral and striatal neuronal degeneration. The onset is typically unilateral, with marked rigidity-dystonia of the involved arm; this differs from MSA.

Cortical signs of apraxia, alien-limb phenomena, cortical sensory loss, and cortical reflex myoclonus are helpful to distinguish between corticobasal ganglionic degeneration and MSA.


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