How do the symptoms of multiple system atrophy (MSA) vary based on which system is involved?

Updated: Oct 17, 2018
  • Author: André Diedrich, MD, PhD; Chief Editor: Selim R Benbadis, MD  more...
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Other symptoms of MSA are based on mixed dysfunction. When the disorder results in nonautonomic features, imbalance caused by cerebellar or extrapyramidal abnormalities is the most common feature.

If the cerebellar, extrapyramidal, and pyramidal systems are involved, the movement disorder is usually the most profound disability.

Vocal cord paralysis may lead to hoarseness and stridor. A neurogenic and obstructive mixed form of sleep apnea can occur.

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