What is the prognosis of autonomic failure syndromes?

Updated: Oct 21, 2018
  • Author: Mohini Gurme, MD; Chief Editor: Selim R Benbadis, MD  more...
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  • The prognosis for autoimmune autonomic neuropathy (AAN) is poor without treatment, and many patients have residual autonomic symptoms. With IVIg therapy, a few patients who are treated early in the disease course can have excellent recovery of function. However, additional patients must be treated to confirm the initial favorable findings.

  • Patients with pure autonomic failure have symptoms that remain confined to the autonomic nervous system. These patients generally improve little over time, and their symptoms may worsen. Some may later develop multiple system atrophy or Parkinson's disease.

  • The prognosis for patients with multiple system atrophy is poor overall. Neurologic function declines gradually over time. The autonomic symptoms often become debilitating. Survival is typically 6-9 years from the time of diagnosis.

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