Which tests may be performed to identify systemic disorders causing secondary pandysautonomia?

Updated: Oct 21, 2018
  • Author: Mohini Gurme, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Tests for systemic disorders causing secondary pandysautonomia, including the following, may be ordered according to clues from the patient’s history:

  • Glycosylated hemoglobin or glucose tolerance test: To test for diabetes

  • Anti-Hu antibody titers: If the patient has associated sensory neuropathy or cognitive changes.

  • Anti-calcium channel antibody titers: For Lambert-Eaton myasthenic syndrome (LEMS)

  • Stool screen for botulinum by culture and detection of toxin: In cases of suspected poisoning by food or wound contamination

  • Serum and urine protein electrophoresis: To evaluate myeloma with amyloidosis

  • Genetic testing: To evaluate for familial amyloidosis

  • Rapid plasma reagent (RPR) or Venereal Disease Research Laboratory test (VDRL): To test for syphilis

  • Human immunodeficiency virus (HIV) testing

  • Autoimmune screening: To evaluate for collagen-vascular disease; may include antinuclear antibody levels, erythrocyte sedimentation rate, and other autoimmune tests (eg, rheumatoid factor, SS-A and SS-B antibodies)

  • Assessment of the urinary porphyrins and erythrocyte porphobilinogen deaminase levels: If the clinical history suggests the possibility of porphyria


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