What are the signs and symptoms of multiple system atrophy?

Updated: Oct 21, 2018
  • Author: Mohini Gurme, MD; Chief Editor: Selim R Benbadis, MD  more...
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Autonomic manifestations are similar to those observed in AAN and PAF. The following neurologic features may also be present:

  • Pyramidal or cerebellar abnormalities: Weakness, ataxia, incoordination, and eye-movement abnormalities may precede the autonomic features by as long as 2 years

  • Variable parkinsonian findings: Found in MSA parkinsonian variant; are unresponsive to levodopa; include rigidity, bradykinesia, tremor, and truncal instability

  • Evidence of cerebellar dysfunction: Found in MSA cerebellar variant; includes ataxia, dysmetria, dysdiadochokinesia, and incoordination; eye-movement abnormalities are frequently present

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