What is the role of the adenosinergic receptor system in the development of tardive dyskinesia (TD)?

Updated: Oct 17, 2018
  • Author: James Robert Brasic, MD, MPH; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Bishnoi et al provided evidence of the involvement of the adenosinergic receptor system in the development of TD in rodents. [11] Haloperidol induced vacuous chewing movements, orofacial movements, and facial stereotypies in rats. These changes were reversed after treatment with adenosine or caffeine. These findings provide evidence that adenosine, a major inhibitory neurotransmitter in the CNS, plays a role in TD. Additionally, these results suggest potential therapeutic agents for clinical trials.


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