What is the role of nicotine in the pathophysiology of tardive dyskinesia (TDs)?

Updated: Oct 17, 2018
  • Author: James Robert Brasic, MD, MPH; Chief Editor: Selim R Benbadis, MD  more...
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Nicotine may play a role in the pathophysiology of TS. Cigarette smokers appear to have increased metabolism of dopamine D2 antagonists. Nicotinic agonists appear to relieve dyskinesias in some people with Tourette syndrome, a condition characterized by the presence of motor and phonic tics. The relation between TD and the use of cigarettes and other nicotinic agonists remains to be clarified. The results of an animal study suggest the possibility that nicotine may be useful for improving the TD associated with antipsychotic use. [7]

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