What is the role of genetics in the pathogenesis of tardive dyskinesia (TD)?

Updated: Oct 17, 2018
  • Author: James Robert Brasic, MD, MPH; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Answer

Most likely, genetic traits produce a vulnerability to TD when a susceptible individual is exposed to particular agents. For example, the MscI polymorphism of the dopamine D3 receptor gene has been associated with the development of TD. Support for the hypothesis that TD may result from blockade of postsynaptic dopamine receptors in the basal ganglia and other parts of the brain exists in the form of the beneficial effects of increasing doses of neuroleptics for some patients with TD. Thus, dopamine antagonists may mask TD.


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