Which polymorphisms are associated with tardive dyskinesia (TD)?

Updated: Oct 17, 2018
  • Author: James Robert Brasic, MD, MPH; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Answer

TD has been associated with polymorphisms of both the dopamine receptor D2 (DRD2) gene [1] , TaqI A and TaqI B and associated haplotypes [2] , and of the dopamine receptor D3 (DRD3) gene [1, 3] , the dopamine transporter (DAT) gene, and the manganese superoxide dismutase (MnSOD) gene.

Dysfunction of the dopamine transporter has been hypothesized to play a role in the development of TD. However, Lafuente et al did not find evidence of involvement of a polymorphism with a variable number of tandem repeats (VNTD) in the DAT gene (SLC6A3) in dyskinesias induced by antipsychotics. [4] Thus, further research is needed to investigate the role of the dopamine transporter in the development and maintenance of TD.

Galecki et al reported the association of a polymorphism of the manganese superoxide dismutase (MnSOD) gene and TD. [5]


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