Which medications in the drug class Nonsteroidal anti-inflammatory drugs (NSAIDs) are used in the treatment of Syringomyelia?

Updated: Nov 10, 2017
  • Author: Hassan Ahmad Hassan Al-Shatoury, MD, PhD, MHPE; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Nonsteroidal anti-inflammatory drugs (NSAIDs)

NSAIDs commonly are used as analgesics in patients with syringomyelia. If one class seems to be ineffective after a 2-week trial, a formulation from another class may be tried. The most commonly used drugs are ibuprofen, acetylsalicylic acid, naproxen, indomethacin, mefenamic acid, and piroxicam.

Ibuprofen (Ibuprin, Advil, Motrin)

One of propionic acid derivatives group. Effective inhibitor of cyclooxygenase, which is responsible for biosynthesis of prostaglandins; rapidly absorbed after PO administration; half-life in plasma is about 2 h; passes slowly into synovial spaces and may remain there in higher concentration as concentrations in plasma decline; excretion is rapid and complete, mainly in urine as metabolites or their conjugates.

Aspirin (Anacin, Ascriptin, Bayer Aspirin)

Treats mild to moderately severe pain and headache. Inhibits prostaglandin synthesis, which prevents formation of platelet-aggregating thromboxane A2; acts on heat-regulating center of hypothalamus and vasodilates peripheral vessels to reduce fever.

Naproxen (Naprelan, Naprosyn, Aleve, Anaprox)

For relief of mild to moderately severe pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which is responsible for prostaglandin synthesis.

Indomethacin (Indocin, Indochron E-R)

Rapidly absorbed. Metabolism occurs in liver by demethylation, deacetylation, and glucuronide conjugation. Inhibits prostaglandin synthesis.

Piroxicam (Feldene)

Decreases activity of cyclooxygenase, which in turn inhibits prostaglandin synthesis. These effects decrease formation of inflammatory mediators.

Mefenamic acid (Ponstel)

Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis


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