What are the relapse rates of multiple sclerosis during pregnancy?

Updated: Aug 20, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Comparison of relapse rates for patients treated with IVIg for the entire pregnancy and relapse rates in the untreated group revealed a positive effect for the former, as follows [60] :

  • First trimester - 0.43 versus 0.72

  • Second trimester - 0.15 versus 0.61

  • Third trimester - 0.0 versus 0.41

  • Postpartum period - 0.28 versus 1.33

Relapse rates also decreased in patients treated with IVIg only after delivery (0.58) as compared with untreated patients (1.33). No significant adverse events were associated with IVIg treatment in patients or newborns. [60]

Haas reported that the exacerbation rate after delivery in IVIg-treated individuals was reduced by 33%. [61] IVIg was administered within 3 days after delivery and then monthly to patients thought to be at high risk for exacerbations. They were compared with patients in the PRIMS study, who, for this study, served as control subjects.

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