What is the role of corticosteroids (methylprednisolone) in the treatment of postpartum multiple sclerosis?

Updated: Nov 08, 2018
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Answer

In one study, 22 patients from 1996 to 1998 who received no treatment for MS after delivery were compared with 20 patients from 1999 to 2001 who were treated with 1 g of intravenous (IV) corticosteroids monthly for the first 6 months post partum. [55] Although the mean relapse rate increased during the first 3 months in both groups, it was higher in the untreated group than in the treated group (2 ± 0.66 versus 0.8 ± 0.41).

The finding from this study suggests that prophylactic treatment with IV corticosteroids may be beneficial during the first 3 months after pregnancy. [55] To the authors’ knowledge, however, no studies have adequately assessed the safety of this approach in breastfeeding women.


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