What is the role of corticosteroids (methylprednisolone) in the treatment of postpartum multiple sclerosis?

Updated: Aug 20, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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In one study, 22 patients from 1996 to 1998 who received no treatment for MS after delivery were compared with 20 patients from 1999 to 2001 who were treated with 1 g of intravenous (IV) corticosteroids monthly for the first 6 months post partum. [58] Although the mean relapse rate increased during the first 3 months in both groups, it was higher in the untreated group than in the treated group (2 ± 0.66 versus 0.8 ± 0.41).

The finding from this study suggests that prophylactic treatment with IV corticosteroids may be beneficial during the first 3 months after pregnancy. [58] To the authors’ knowledge, however, no studies have adequately assessed the safety of this approach in breastfeeding women.

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