What is the prevalence of major congenital malformations from specific AEDs?

Updated: Nov 08, 2018
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
  • Print
Answer

Answer

Data are available from the NAAED pregnancy registry with regard to major malformations associated with monotherapy. The rates for particular AEDs are as follows [24] :

  • Phenobarbital (n = 77) - 6.5%

  • Valproic acid (n = 143) - 10.7%

  • Other AED (n = 1048) - 2.9%

  • No AED (active malformation surveillance program) - 1.62%

Data from the Lamotrigine Pregnancy Registry showed rates of 2% with monotherapy and 12.1% for lamotrigine plus valproic acid. One study reported a rate of fetal death or major congenital malformations of 20% for valproic acid, 11% for phenytoin, 8% for carbamazepine, and 1% for lamotrigine. [25]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!