What are the AAN/AES guidelines for the use of antiepileptic drugs during pregnancy?

Updated: Aug 20, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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The AAN/AES guidelines state that there probably is no substantially increased (> 2 times expected) risk of cesarean delivery or late pregnancy bleeding, and no moderately increased (> 1.5 times expected) risk of premature contractions or premature labor and delivery in pregnant women taking AEDs. However, for women with epilepsy who smoke, there may be a substantially increased risk of premature contractions and premature labor and delivery during pregnancy.

In addition, the guidelines state that women with epilepsy who are seizure-free for at least 9 months before pregnancy probably have a high likelihood (84-92%) of remaining seizure-free during pregnancy.

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