Which medications in the drug class Skeletal Muscle Relaxants are used in the treatment of Cauda Equina and Conus Medullaris Syndromes?

Updated: Jun 14, 2018
  • Author: Segun Toyin Dawodu, JD, MD, MS, MBA, LLM, FAAPMR, FAANEM; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Skeletal Muscle Relaxants

These agents are thought to work centrally by suppressing conduction at the spinal level.

Baclofen (Lioresal, Gablofen)

Baclofen may induce hyperpolarization of afferent terminals and inhibit both monosynaptic and polysynaptic reflexes at the spinal level.

Dantrolene (Dantrium, Revonto)

Dantrolene stimulates muscle relaxation by modulating skeletal muscle contractions at sites beyond the myoneural junction and acting directly on muscle itself. It prevents calcium release from sarcoplasmic reticulum.


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