Which medications in the drug class Neuromuscular Blocker Agent, Toxin are used in the treatment of Cauda Equina and Conus Medullaris Syndromes?

Updated: Jun 14, 2018
  • Author: Segun Toyin Dawodu, JD, MD, MS, MBA, LLM, FAAPMR, FAANEM; Chief Editor: Nicholas Lorenzo, MD, CPE, MHCM, FAAPL  more...
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Neuromuscular Blocker Agent, Toxin

These agents inhibit transmission of impulses in neuromuscular tissue.

OnabotulinumtoxinA (BOTOX)

This agent binds to receptor sites on motor nerve terminals and inhibits release of acetylcholine, which in turn inhibits transmission of impulses in neuromuscular tissue.

It is most useful for treating spasticity in the gastrocnemius and soleus muscles; less effective in larger muscles such as quadriceps. Re-examine patients 7-14 d after initial dose, to assess for response. It may be repeated q3-4mo.

Also indicated for urinary incontinence in patients with neurologic conditions (eg, spinal cord injury, multiple sclerosis) in adults who have an inadequate response to or are intolerant of an anticholinergic medication. Intradetrusor injections are administered about every 9 months.

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