Which medications in the drug class Phosphodiesterase (type 5) Enzyme Inhibitors are used in the treatment of Cauda Equina and Conus Medullaris Syndromes?

Updated: Jun 14, 2018
  • Author: Segun Toyin Dawodu, JD, MD, MS, MBA, LLM, FAAPMR, FAANEM; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Phosphodiesterase (type 5) Enzyme Inhibitors

These agents increase the vasodilatory effects of nitric oxide by inhibiting the enzyme phosphodiesterase type 5, which in turn increases sensitivity for erections.

Sildenafil (Viagra)

Sildenafil is a phosphodiesterase type 5 (PDE5) selective inhibitor. Inhibition of PDE5 increases the activity of cyclic guanosine monophosphate (cGMP), which increases the vasodilatory effects of nitric oxide. This agent is effective in men with mild-to-moderate ED.

Vardenafil (Levitra, Staxyn)

Vardenafil is a PDE5 selective inhibitor. Inhibition of PDE5 increases cGMP activity, which increases the vasodilatory effects of nitric oxide. It is effective in men with mild-to-moderate ED.

Take on an empty stomach about 1 h before sexual activity. Sexual stimulation is necessary to activate response. Increased sensitivity for erections may last 24 h. Vardenafil is available as 2.5-mg, 5-mg, 10-mg, and 20-mg tabs.

Tadalafil (Cialis)

Tadalafil is a PDE5 selective inhibitor. Inhibition of PDE5 increases cGMP activity, which increases the vasodilatory effects of nitric oxide. Sexual stimulation is necessary to activate response. Increased sensitivity for erections may last 36 h. Tadalafil is available as 2.5-mg, 5-mg, 10-mg, and 20-mg tabs.


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