Which medications in the drug class Antimalarials are used in the treatment of Neurosarcoidosis?

Updated: Nov 13, 2018
  • Author: Gabriel Bucurescu, MD, MS; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Answer

Antimalarials

The antimalarial agents chloroquine phosphate and hydroxychloroquine sulfate have been used in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects.

Chloroquine phosphate (Aralen)

Chloroquine produces an anti-inflammatory effect by suppressing lymphocyte transformation and may have a photoprotective effect.

Hydroxychloroquine (Plaquenil)

Hydroxychloroquine inhibits chemotaxis of eosinophils and locomotion of neutrophils and impairs complement-dependent antigen-antibody reactions. Hydroxychloroquine sulfate 200 mg is equivalent to 155 mg hydroxychloroquine base and 250 mg chloroquine phosphate.


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