What is the role of blood studies in the workup of neurosarcoidosis?

Updated: Nov 13, 2018
  • Author: Gabriel Bucurescu, MD, MS; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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The erythrocyte sedimentation rate (ESR) may be elevated in systemic sarcoidosis. Creatine kinase, ESR, and aldolase may be useful in cases of myopathy.

Tests for hyperglycemic states should be performed, including fasting glucose and glycosylated hemoglobin levels to exclude diabetes mellitus. If those results are normal, a 2-hour oral glucose tolerance test is needed.

A serum vitamin B-12 level should be measured to exclude deficiency. If the level is on the low side, the diagnosis should be pursued by measuring serum homocysteine and methylmalonic acid levels, which are expected to be high in B-12 deficiency.

Blood urea nitrogen (BUN), creatinine, and serum calcium should be checked to rule out long-standing metabolic derangements, which can result in neuropathy. Hypercalcemia is a known feature of systemic sarcoidosis, and abnormalities of renal functions may reflect a wider involvement of the primary disease process.

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