How is neurosarcoidosis diagnosed?

Updated: Nov 13, 2018
  • Author: Gabriel Bucurescu, MD, MS; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Answer

Definitive diagnosis of neurosarcoidosis requires the exclusion of other causes of neuropathy and the identification of noncaseating sarcoid granulomas by histologic analysis of nerve and muscle biopsy specimens. Other studies and diagnostic procedures may include the following:

  • Blood studies

  • Serum protein immune electrophoresis

  • Lumbar puncture with cerebrospinal fluid (CSF) analysis

  • Chest radiography

  • Magnetic resonance imaging (MRI)

  • Fluorodeoxyglucose positron emission tomography (FDG-PET)

  • Electromyography/nerve conduction studies (EMG/NCS)

  • Evoked potential (EP) studies

  • Optical coherence tomography (OCT)


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