What are the signs and symptoms of CNS involvement in neurosarcoidosis?

Updated: Nov 13, 2018
  • Author: Gabriel Bucurescu, MD, MS; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Answer

Central nervous system involvement may affect the hypothalamus/pituitary gland, cerebral cortex, cerebellum, and spinal cord (rarely), resulting in the following:

  • Polydipsia

  • Polyuria

  • Diabetes insipidus

  • Changes in appetite

  • Changes in sleep cycle (somnolence, hypersomnia [18] )

  • Impaired temperature regulation (hyperthermia, hypothermia)

  • Obesity

  • Alveolar hypoventilation

  • Impotence

  • Change in menstrual period

  • Galactorrhea

  • Amenorrhea

  • Generalized confusion

  • Dementia

  • Amnesia, both short term and long term

  • Loss of judgment

  • Acalculia

  • Generalized fatigue

  • Headache

  • Meningitis

  • Corticospinal signs

  • Cerebellar signs

  • Brainstem signs

  • Cerebral infarct or transient ischemic attack

  • Seizures

  • Kleine-Levine-Critchley syndrome (rare) [19]

  • Parkinsonism (with basal ganglia infiltration) [20]

  • Hydrocephalus [21]

  • Sudden death [22]


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