What is the global prevalence of neurosarcoidosis?

Updated: Nov 13, 2018
  • Author: Gabriel Bucurescu, MD, MS; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Answer

The incidence of sarcoid varies from 0.04 cases per 100,000 population in Spain to 64 cases per 100,000 population in Sweden. The prevalence in London was found to be 27 cases per 100,000 population for patients born in the United Kingdom, 97 cases per 100,000 population among Irishmen, and 200 cases per 100,000 population in men from the West Indies (5%). In southwest England and south Wales, one study showed a prevalence of 1 in 100 000 in a population of about 3 million. [6] One study done in Paris showed that 13% of individuals from Martinique were affected with sarcoid.

In Asia, sarcoid is extremely rare, being almost unknown in Chinese and Southeast Asians. Data from Japan showed native Japanese to be affected.

In a prospective study from Australia, Allen et al reported neurologic involvement in 26% of white patients with sarcoidosis (32 of 123). The following frequencies of neurologic abnormalities were observed [7] :

  • Papilledema (6%)

  • Cranial neuropathy (59%)

  • Peripheral neuropathy (47%)

  • Mononeuropathy (25%)

  • Myopathy (25%)

  • Psychiatric disorders (19%)

  • Cerebellar ataxia (13%)

  • Hydrocephalus (6%)


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