What is the prevalence of neurosarcoidosis in the US?

Updated: Nov 13, 2018
  • Author: Gabriel Bucurescu, MD, MS; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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The prevalence of sarcoid varies widely, but generally it is more common in African Americans. In the southeastern United States, the prevalence is much higher in both blacks and whites than in the rest of the country. In New York, the prevalence is 30 cases per 100,000 population.

In Los Angeles, Mexican immigrants constituted 7% of the observed cases, compared with 82% for blacks.

The frequency of neurologic involvement is generally 5% of all cases of sarcoid, [5] but in some series it was noted to vary from 5-16%. In one prospective study, neurologic complications occurred in 32 of 123 (26%) patients with sarcoidosis. These figures are considered to be underestimates because of the usually silent manifestation of the disease and unavailability of tissue diagnosis in all cases.

Neurosarcoidosis occurs in approximately 5% of patients with sarcoidosis, and approximately half the patients with neurosarcoidosis present with neurologic difficulties when sarcoidosis is first diagnosed. Peripheral neuropathy is seen in 5-15% of those with neurosarcoidosis. In a series from Johns Hopkins University, 2 of 33 patients with neurosarcoidosis had peripheral neuropathy; of this population, 85% was African American and 15% was white. Pediatric neurosarcoidosis is rarely reported.

Neurosarcoidosis is also seen in the Puerto Rican population, reaching a prevalence as high as 175 cases per 100,000 population in one retrospective study.

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