Which medications in the drug class Acetylcholinesterase Inhibitors, Central are used in the treatment of Multiple Sclerosis?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Acetylcholinesterase Inhibitors, Central

Multiple sclerosis may affect cognition, and cognition-enhancing drugs have been met with some success in MS patients. Treatments used in Alzheimer disease, such as donepezil (Aricept), may have some potential beneficial effects; however, it has not been proven in clinical trials. Donepezil is not FDA-approved for use in MS. Depression may also contribute to cognitive dysfunction and should be treated if it is diagnosed.

Donepezil (Aricept)

Donepezil selectively inhibits acetylcholinesterase, the enzyme responsible for the destruction of acetylcholine, and improves the availability of acetylcholine.

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