Which medications in the drug class Antispasmodic Agents, Urinary are used in the treatment of Multiple Sclerosis?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Antispasmodic Agents, Urinary

Treatment of bladder dysfunction in MS patients includes suppressing urgency and ensuring effective urinary drainage. Antispasmodic agents that help decrease muscle spasms of the bladder and the frequent urge to urinate caused by spasms include oxybutynin (Ditropan, Ditropan XL) or tolterodine (Detrol, Detrol LA).

Tolterodine (Detrol, Detrol LA)

Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors.

Oxybutynin (Gelnique, Ditropan XL, Oxytrol)

Oxybutynin is an antispasmodic that exerts a direct effect on smooth muscle and inhibits the muscarinic effects of acetylcholine on smooth muscle. This results in relaxation of bladder smooth muscle. It is indicated for the relief of urinary symptoms in patients with uninhibited and reflex neurogenic bladder. It is metabolized by the liver and excreted renally.

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