Which medications in the drug class Nonsteroidal Anti-Inflammatory Drugs are used in the treatment of Multiple Sclerosis?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Nonsteroidal Anti-Inflammatory Drugs

Pharmacologic agents used for the treatment of secondary pain in MS are nonsteroidal anti-inflammatory drugs (NSAIDs) or other analgesics. Ibuprofen has also been cited as potentially having beneficial effects with paroxysmal symptoms. The use of narcotics seldom is indicated. Commonly used NSAIDs include ibuprofen (Motrin, Advil) and naproxen (Naprosyn, Aleve, Anaprox, Anaprox DS, Naprelan).

Ibuprofen (Motrin, Advil, Caldolor, Addaprin, Dyspel, Genpril)

Ibuprofen is the drug of choice for patients with mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Naproxen (Naprosyn, Aleve, Anaprox DS, Naprelan, Naproxen DR)

Naproxen is used for relief of mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing activity of cyclo-oxygenase, which is responsible for prostaglandin synthesis.

Diclofenac (Cambia, Zipsor, Zorvolex)

Diclofenac inhibits prostaglandin synthesis by decreasing COX activity, which, in turn, decreases formation of prostaglandin precursors.

Indomethacin (Indocin, Tivorbex)

Indomethacin is thought to be the most effective NSAID for the treatment of AS, although no scientific evidence supports this claim. It is used for relief of mild to moderate pain; it inhibits inflammatory reactions and pain by decreasing the activity of COX, which results in a decrease of prostaglandin synthesis.


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