Which medications in the drug class Neuromuscular Blockers, Botulinum Toxins are used in the treatment of Multiple Sclerosis?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Neuromuscular Blockers, Botulinum Toxins

The FDA has approved the use of botulinum toxin (Botox) for the treatment of upper limb spasticity in MS. The FDA has also approved this agent for the treatment of urinary incontinence due to detrusor overactivity associated with a neurologic condition (eg, MS) in adults who have an inadequate response to, or are intolerant of, an anticholinergic medication.

OnabotulinumtoxinA toxin (Botox)

OnabotulinumtoxinA toxin is an injectable neurotoxin that temporarily blocks connections between the nerves and the muscles, leading to short-term relaxation of the targeted muscle. The drug can be injected again when the muscle-relaxing effects have worn off, but not more frequently than every 3 months.

It is approved for the treatment of upper limb spasticity in adults to decrease the severity of increased muscle tone in elbow flexors (biceps), wrist flexors (flexor carpi radialis and flexor carpi ulnaris), and finger flexors (flexor digitorum profundus and flexor digitorum sublimis).

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