Which medications in the drug class Skeletal Muscle Relaxant are used in the treatment of Multiple Sclerosis?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Skeletal Muscle Relaxant

Pharmacologic treatment of spasticity includes baclofen (Lioresal, Gablofen) as a first-line agent. Baclofen can be titrated easily in divided doses. Patients using this medication may report fatigue or weakness as an adverse effect. Dantrolene (Dantrium) acts within muscles on excitation-contraction coupling; however, it is rarely used because it can cause liver damage.

Baclofen (Lioresal, Gablofen)

Baclofen is a skeletal muscle relaxant used as a first-line treatment for spasticity in patients with MS. It can effectively relieve spasms and has modest effects in improving performance. Intrathecal baclofen via an implanted pump can be effective against spasticity in suitable patients. The pump can be electronically regulated to deliver small amounts of baclofen at a constant or variable dose over a 24-hour period to increase efficacy and decrease side effects.

Dantrolene (Dantrium, Revonto, Ryanodex)

Dantrolene is a skeletal muscle relaxant that acts directly on skeletal muscle to decrease spasticity. Dantrolene is believed to decrease muscle contraction by directly interfering with calcium ion release from the sarcoplasmic reticulum within skeletal muscle cells. It affects all muscles of the body and is used less frequently than baclofen because of hepatotoxicity at higher doses and numerous drug interactions.

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