What is myelocortical multiple sclerosis (MCMS)?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Myelocortical MS (MCMS) is a new subtype of MS identified in 2018. It is marked by demyelination of the spinal cord and cerebral cortex but not of cerebral white matter. Researchers studied the brain and spinal cords from 100 patients with MS who had died between May 1998 and November 2012. Twelve of these individuals (12%) had demyelinated lesions in the spinal cord and cerebral cortex, but not in cerebral white matter. Researchers then compared the demyelinated lesion area in tissue sections of cerebral white matter, spinal cord, and cerebral cortex of individuals with MCMS with those collected from individuals with traditional MS and found that only the typical MS patients had lesions in the cerebral white matter. This suggests that neurodegeneration can be independent of demyelination in MCMS patients. [32]


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