What have the DECIDE and SELECT studies shown about the effectiveness of daclizumab (Zinbryta) in the treatment of relapsing multiple sclerosis (MS)?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Daclizumab (Zinbryta) was approved by the FDA in May 2016 for relapsing forms of MS. It is a humanized monoclonal antibody that binds to the high-affinity interleukin-2 (IL-2) receptor subunit (CD25). These subunits are expressed at high levels on T-cells that become abnormally activated in multiple sclerosis. Approval was based on results from 2 trials, DECIDE and SELECT, in which daclizumab 150 mg was administered SC every 4 wk in people with relapsing-remitting MS. In the DECIDE trial, daclizumab was compared with interferon beta-1a (30 mcg/wk IM). The annualized relapse rate was lower with daclizumab than with interferon beta-1a (0.22 vs. 0.39; 45% lower rate with daclizumab; P< 0.001). [23] The SELECT trial showed that the annualized relapse rate was lower for patients given daclizumab compared with placebo (54% reduction, 95% CI 33-68%; p< 0·0001). [24]

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