Which conditions should be excluded by blood tests in suspected multiple sclerosis (MS)?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Results of blood studies are usually normal in MS patients. Perform blood work to help exclude conditions such as the following:

  • Collagen vascular disease and other rheumatologic conditions

  • Infections (ie, Lyme disease, syphilis)

  • Endocrine abnormalities (eg, thyroid disease)

  • Vitamin B12 deficiency

  • Sarcoidosis

  • Vasculitis

Neuromyelitis optica (NMO, or Devic disease) can be confirmed by the presence of serum antibodies against aquaporin 4, a water channel expressed at major fluid-tissue barriers across the CNS. [33]

In patients with movement disorders and ocular manifestations, copper studies may be useful. Wilson disease has been misdiagnosed as MS. [61]


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