What are the advantages and limitations of the 10-point Kurtzke Expanded Disability Status Scale (EDSS) in multiple sclerosis (MS)?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Advantages of the EDSS are that it is widely used clinically, is easy to administer, and requires no special equipment. Its limitations are as follows:

  • It is heavily dependent on mobility

  • It is somewhat subjective in certain areas (eg, bowel and bladder function)

  • It is insensitive to small changes

  • It does not present an accurate picture of the patient's cognitive abilities and functional abilities in performing activities of daily living (ADLs)

  • It is nonlinear in terms of the time spent at various ranges of the scale

Despite its limitations, the EDSS is often used as a standardization measure for clinical trials.


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