Which medications are used to treat the symptoms of multiple sclerosis (MS)?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Treatment of the symptoms of MS involves both pharmacologic and nonpharmacologic measures. The following symptoms may be amenable to pharmacologic therapy:

  • Fatigue: Off-label treatments include amantadine, methylphenidate, and fluoxetine

  • Depression: Selective serotonin reuptake inhibitors are preferred

  • Spasticity: Baclofen is effective in most cases

  • Pain: Tricyclic antidepressants are first-line drugs for primary pain

  • Sexual dysfunction: Oral phosphodiesterase type 5 inhibitors (eg, sildenafil, tadalafil, vardenafil)

  • Optic neuritis: Intravenous methylprednisolone may speed recovery

See Treatment and Medication for more detail.

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