What are the possible adverse effects of ketamine for the treatment of complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Answer

CNS side effects can include dysphoria, hallucinations, night terrors, and flashbacks. Advised precautions include daily comprehensive metabolic profiles to ensure that no abnormalities in liver function develop. Data from one center showed that ketamine infusion was provided on an outpatient basis for refractory or otherwise difficult cases of CRPS; 66-80% of those patients showed an overall improvement as measured by increased function, reduced medication requirements, or both. [134, 137]


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