What is the role of clonidine in the treatment of complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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A small, uncontrolled study of patients with CRPS with SMP reported reduced allodynia from transdermal clonidine, but only in the skin directly under the transdermal patch. [98] Clinical experience has been scant with systemic clonidine, but occasional case reports have shown that some patients achieved significant relief without intolerable side effects. [99, 100] No controlled, long-term, and/or prospective studies designed to assess the efficacy of systemic clonidine have yet been published. However, a new formulation of topical clonidine gel with minimal systemic activity was studied in an open-label, uncontrolled pilot study that decreased allodynia and hyperalgesia in some patients with CRPS. [101]

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