What is the role of oral sympatholytic agents in the treatment of complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Answer

Like sympathetic blocks, oral sympatholytic agents should, in theory, provide symptom and pain relief for patients with CRPS and other neuropathic SMP. However, no randomized, prospective, controlled study has assessed the efficacy of these agents [1] , although case reports and case series have reported benefit from prazosin [95] , phenoxybenzamine [96] , and terazosin. [97] The clinical use of these drugs is frequently fraught with adverse side effects, including orthostatic hypotension and depression. [1]


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