What is the role of gamma-aminobutyric acid (GABA) agonists in the treatment of complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Answer

Intrathecally administered baclofen has been shown to be an effective treatment for dystonia and CRPS. [89] No other trials of GABA agonists being used to treat CRPS have been published. No evidence supports baclofen, valproic acid, vigabatrin, or benzodiazepines having an analgesic effect for CRPS or other neuropathic pain conditions. [59]


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