What is the role of calcium-regulating drugs in the treatment of complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Answer

Calcitonin administered intranasally tid has been demonstrated to significantly reduce pain in patients with CRPS. [81] Intravenous (IV) clodronate (300 mg daily) and alendronate (either 7.5 mg/d IV or 40 mg/d orally) have been shown to significantly improve pain, swelling, and range of movement in patients with acute CRPS. [82, 83, 84] The mechanism of action of these compounds is unknown.


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