What is the role of peripheral nerve biopsy in the evaluation of complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Answer

In the affected extremities, efferent nerve fibers are unchanged histologically; with afferent fibers, only C fibers have demonstrated histopathological abnormalities, which consist of denervation of the Schwann cell stacks, miniature axon sprouts, and an obvious increase in collagen pockets. C-fiber loss may be noted as well. Sometimes, multiple basal membranes surround the small endoneural vessels.


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