Which conditions should be included in the differential diagnoses of complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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  • Brain (stroke, neoplasm, encephalitis)

  • Spinal cord (trauma, transverse myelitis, either structural or tumor-related syringomyelia)

  • Tabies dorsalis

  • Multiple sclerosis

  • Poliomyelitis


  • Structural (eg, due to structural impingement of a diskal, osteophyte-, or tumor-related nature)

  • Metabolic (eg, diabetes, vasculitis infectious)

  • Neoplastic


  • Infectious

  • Autoimmune/idiopathic

  • Tumor (primary or secondary neoplasm), especially Pancoast syndrome

  • Trauma (macro or cumulative)

  • Entrapment (thoracic outlet syndrome)


Vascular disorders

  • Peripheral atherosclerotic disease

  • Arterial insufficiency

  • Phlebothrombosis

Monomelic amyotrophy


Movement disorders

Metabolic or systemic (eg, renal failure, amyloidosis)

Autoimmune or rheumatological disorder

Infectious (eg, viral, fungal, Lyme) Iatrogenic (eg, prescribed medication)

Demyelinating (CIDP, paresis or sensory deficiency due to multiple sclerosis)

Toxic exposure (eg, vinca alkaloids, heavy metals)

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