Which patient groups have the highest incidence of complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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CRPS affects all races; no differences in incidence or prevalence have been observed.

Females experience CRPS more commonly than males do by a ratio that varies from 2:1 to 4:1. [14, 55, 47, 56, 57, 4, 58]

CRPS is distributed across age groups, but reaches its peak incidence between 37 and 50 years. [14, 55, 47, 56, 57, 4, 58] CRPS has an increased incidence in adolescents, compared with children, with females affected more frequently at a ratio of 4:1 and increased occurrence in the lower extremities rather than the upper by a ratio of 5.3:1. The mean age of onset is 12.5 years in a cohort of 396 children. The highest incidence of the disease appears to be in adults aged 40-49 years. CRPS appears frequently in almost every age group except children. CRPS type I has been seen in children, but the incidence is much lower than in adults.

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